- Continued, unexplained weight loss
- Headaches, often with early-morning vomiting
- Increased swelling or persistent pain in bones, joints, back, or legs
- Lump or mass, especially in the abdomen, neck, chest, pelvis, or armpits
- Development of excessive bruising, bleeding, or rash
- Constant infections
- A whitish color behind the pupil
- Nausea that persists or vomiting without nausea
- Constant tiredness or noticeable paleness
- Eye or vision changes that occur suddenly and persist
- Recurrent or persistent fevers of unknown origin